Rituximab-induced acute thrombocytopaenia in an African lupus patient: A case report

Authors

  • Akpabio A. A.
  • Nga C. N.
  • Udofia U. K.
  • Asuka E. S.
  • Orji P. N.

Keywords:

Rituximab, acute thrombocytopenia, lupus, case report, African

Abstract

Drug-induced acute thrombocytopaenia (DITP) is a complication of various medications resulting in a platelet count <50 x 109/L from prior normal levels. It typically occurs within 1-2 weeks post-administration but can occur rapidly within 1-3 days with previous exposure. Rituximab (an anti-CD20 antibody) used to treat many autoimmune cytopaenias, has been reported to cause thrombocytopaenia mostly in lymphoma patients.

Reports in lupus are rare possibly because of off-label use. We hereby highlight the case of a 39-year old African lady who developed acute thrombocytopenia 12 days post-rituximab. Frequent monitoring of blood counts will enhance identification and treatment of this complication.

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Published

01-12-2020

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