A synopsis on optimising fluid therapy in sepsis: challenges in resource-limited settings

Abstract

Fluid therapy is a cornerstone of sepsis management, yet controversy surrounds several aspects of its administration. Optimising fluid therapy in sepsis requires a nuanced understanding of the underlying pathophysiology, patient-specific factors, and the latest evidence. This review summarises the current evidence on fluid therapy in sepsis, highlights challenges in low—and lower-middle-income countries (LMICs), and areas of future research (burden of sepsis, appropriate fluid management, role of care bundles, etc).