Chromophobe: A rare histological variant of renal cell carcinoma

Adekunle AA; Idowu NA; Rasheed MW; Aderibigbe OA; Olatide OO

doi:10.61386/imj.v16i3.338

Authors

Adekunle AA Department of Morbid Anatomy and Histopathology, Ladoke Akintola University of Technology Teaching Hospital and LAUTECH Ogbomosho, Nigeria
Idowu NA Urology Division, Department of Surgery, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Nigeria https://orcid.org/0000-0003-4231-7703
Rasheed MW Department of Anatomic Pathology, Federal Medical Centre, Birnin Kudu Jigawa State, Nigeria
Aderibigbe OA Department of Morbid Anatomy and Histopathology, Ladoke Akintola University of Technology Teaching Hospital and LAUTECH Ogbomosho, Nigeria
Olatide OO Department of Surgery, Division of Orthopedic Ladoke Akintola University of Technology Teaching Hospital and LAUTECH Ogbomoso, Nigeria

DOI:

https://doi.org/10.61386/imj.v16i3.338

Keywords:

Renal cell carcinoma, chromophobe, immunohistochemistry

Abstract

Background: Renal cell carcinoma (RCC) is an adenocarcima of the kidney. It is a highly heterogeneous disease with sixteen known subtypes out of which five predominate. The most common subtype is clear cell RCC which accounts for 75-85%. The chromophobe subtype of RCC is rarely seen. It is reported to constitute 4-5% of RCC subtype. This study was aimed at reporting the first case of chromophobe renal cell carcinoma in our community a rare histological subtype of RCC which was discovered incidentally. Our objective was to describe the clinical, histological and immunohistochemical evaluation of a case of chromophobe RCC.

Case report: We present a 60-year-old man who was seen at the surgical outpatient department of our center with a request for general health check-up. He had basic laboratory and imaging investigations. These were essentially normal except for an incidental finding of a left renal mass on abdominopelvic sonogram. Computed tomography urography showed a suspected clinically localized malignant left renal mass. Histological and immunohistochemistry are consistent with a chromophobe RCC. His clinic follow-up remains unremarkable.

Conclusion: We reported the clinical, histological and immunohistochemical evaluation of a rare case of chromophobe RCC. This was discovered incidentally following general health check. He had open radical nephrectomy and clinic follow-up 1 year after discharge has been uneventful.