Administration of banana green peel ethanolic extract to carbontetrachloride-induced albino wistar rats offers slight hepato-protection

Authors

  • Edagha I. A. Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Nigeria
  • Ekpo A. J.
  • Effiong H. D.

Keywords:

Green Banana Peel, Liver function, Histology, Wistar Rat

Abstract

Effect of banana green peels ethanolic extract on the liver function and histology of albino Wistar rats treated with intraperitoneal administration of 4 ml/kg body weight of Carbontetrachloride (CCl4) was investigated. 30 Wistar rats were divided into 6 groups of 5 each as follows: Group 1 (normal control) and 2 (CCl4 group) received normal feed and 4 ml/kg body weight CCl4 plus olive oil respectively; Group 2 were CCl4-induced on day 21; Group 3 received 1 ml/kg body weight tween 80 plus olive oil; Group 4, 5 and 6 were also CCl4-induced at 4 ml/kg body weight, and then administered 500mg/kg body weight of green banana peels, 1000 mg/kg body weight of green banana peels, and 100 mg of Vitamin C respectively. Animals were sacrificed after 21 days of treatment. Serum samples and liver organs were collected for liver function profile, and haematoxylin and eosin (H&E) histological analyses. Result showed a significant (p<0.05) decrease in levels of albumin, aspartate transaminase (AST) and alkaline phosphatase (ALP) (except alanine transaminase (ALT) that was significantly (p<0.05) increased when compared with positive control group). The histology of extract treated groups 4 and 5 showed prominent derangement of hepatocytes but was less severe when compared to CCl4-induced group. Hepatotoxic effect of CCl4 on the liver was positively modulated in the Vitamin C treated Group 6. In conclusion, the ethanolic green banana peels extract possess very mild hepato-protective effect on the histomorphology and altered liver function enzymes.

Published

01-08-2017

Issue

Section

Articles