A study to evaluate the efficacy of intravenous Magnesium Sulphate administration on lactate clearance in critically ill patients

Rani A; Ghai A; Puhal S; Bansal P; Varghese V

doi:10.61386/imj.v17i3.481

Authors

Rani A Department of Anaesthesia and Critical Care, Pandit Bhagwat Dyal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
Ghai A Department of Anaesthesia and Critical Care, Pandit Bhagwat Dyal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, IndiaDepartment of Anaesthesia and Critical Care, Pandit Bhagwat Dyal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
Puhal S Department of Anaesthesia and Critical Care, Pandit Bhagwat Dyal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India https://orcid.org/0000-0003-1234-1796
Bansal P Department of Anaesthesia and Critical Care, Pandit Bhagwat Dyal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
Varghese V Department of Anaesthesia and Critical Care, Pandit Bhagwat Dyal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India

DOI:

https://doi.org/10.61386/imj.v17i3.481

Keywords:

Magnesium sulphate, lactate clearance, critically ill patients

Abstract

Background: Magnesium (Mg) is crucial for normal mitochondrial function in human body. It functions as an important cofactor for numerous biological reactions involving ATP-generating enzymes such as mitochondrial ATP synthase and Na+/K+ ATPase.

Method: This prospective, randomized, interventional study involving two groups of critically ill patients in ICU with hypomagnesaemia. One group received intravenous administration of magnesium sulphate while the second group received intravenous administration of placebo.

Results: Comparison of serum lactate levels between cases and controls (n = 84) was statistically insignificant. Lactate clearance between cases and controls was comparable. Comparison of arterial blood gases between cases and controls was found to be statistically insignificant. Comparison of biochemical parameters between cases and controls. Hospital stay duration of cases and controls was found to be comparable. Mortality between cases and controls was comparable.

Conclusion: There was a significant proportion of critically ill patients with serum hypomagnesemia however intravenous magnesium sulphate administration did not significantly affect the lactate clearance, the days on mechanical ventilation, duration of ICU stay or the mortality.